Motif ID: TLX1..3_NFIC{dimer}.p2

Z-value: 1.130


Transcription factors associated with TLX1..3_NFIC{dimer}.p2:

Gene SymbolEntrez IDGene Name
TLX1 3195 T-cell leukemia homeobox 1
TLX3 30012 T-cell leukemia homeobox 3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
TLX1hg19_v1_chr10_+_102891060_1028912970.215.8e-01Click!


Activity profile for motif TLX1..3_NFIC{dimer}.p2.

activity profile for motif TLX1..3_NFIC{dimer}.p2


Sorted Z-values histogram for motif TLX1..3_NFIC{dimer}.p2

Sorted Z-values for motif TLX1..3_NFIC{dimer}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TLX1..3_NFIC{dimer}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_12200339 2.226 TIMP4
TIMP metallopeptidase inhibitor 4
chrX_-_129519420 2.159 NM_178471
GPR119
G protein-coupled receptor 119
chr1_+_203595897 1.610 NM_001001396
NM_001684
ATP2B4

ATPase, Ca++ transporting, plasma membrane 4

chr15_-_83621350 1.440 NM_004839
NM_199330
HOMER2

homer homolog 2 (Drosophila)

chr1_+_203595929 1.355 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr3_-_12200850 1.250 NM_003256
TIMP4
TIMP metallopeptidase inhibitor 4
chr19_+_15751706 1.138 NM_000896
NM_001199208
NM_001199209
CYP4F3


cytochrome P450, family 4, subfamily F, polypeptide 3


chr17_-_76921076 1.076 TIMP2
TIMP metallopeptidase inhibitor 2
chr19_-_35454952 1.070 NM_175872
ZNF792
zinc finger protein 792
chr1_+_200993041 1.029


chr6_+_135502521 0.991 MYB
v-myb myeloblastosis viral oncogene homolog (avian)
chr1_-_160001529 0.975 PIGM
phosphatidylinositol glycan anchor biosynthesis, class M
chr17_-_76921205 0.951 TIMP2
TIMP metallopeptidase inhibitor 2
chr1_+_203596222 0.946 ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chrX_+_106171328 0.928 CLDN2
claudin 2
chr5_-_111093251 0.890 NM_001142479
NM_001142480
NM_001142478
C5orf13


chromosome 5 open reading frame 13


chr19_-_35454867 0.887 ZNF792
zinc finger protein 792
chr6_-_30128688 0.872 NM_006778
NM_052828
TRIM10

tripartite motif containing 10

chr1_-_16539103 0.867 NM_153213
ARHGEF19
Rho guanine nucleotide exchange factor (GEF) 19
chrX_+_99899162 0.839 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr5_-_111092865 0.776 C5orf13
chromosome 5 open reading frame 13
chr5_-_111093030 0.768 NM_001142482
NM_001142481
C5orf13

chromosome 5 open reading frame 13

chr7_-_16844606 0.764 NM_006408
AGR2
anterior gradient 2 homolog (Xenopus laevis)
chr5_-_111092918 0.764 NM_004772
C5orf13
chromosome 5 open reading frame 13
chr7_+_1127722 0.757 NM_001098201
GPER
G protein-coupled estrogen receptor 1
chr6_-_111927059 0.726 TRAF3IP2
TRAF3 interacting protein 2
chr12_-_122296619 0.714 NM_002150
HPD
4-hydroxyphenylpyruvate dioxygenase
chr14_+_85996512 0.686 FLRT2
fibronectin leucine rich transmembrane protein 2
chr17_+_77893155 0.656


chr18_-_74728677 0.653 MBP
myelin basic protein
chr17_-_76921453 0.645 NM_003255
TIMP2
TIMP metallopeptidase inhibitor 2
chr9_+_116356199 0.643 NM_144489
RGS3
regulator of G-protein signaling 3
chr1_-_23886284 0.632 NM_002167
ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr3_-_14989616 0.623 LOC100505641
uncharacterized LOC100505641
chr16_-_28550324 0.618 NM_001042483
NM_012385
NUPR1

nuclear protein, transcriptional regulator, 1

chr14_+_85996454 0.610 NM_013231
FLRT2
fibronectin leucine rich transmembrane protein 2
chr7_+_116165089 0.604 CAV1
caveolin 1, caveolae protein, 22kDa
chr1_+_145477018 0.603 NM_153713
LIX1L
Lix1 homolog (mouse)-like
chr4_-_103245468 0.588 NM_001135148
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr8_-_30002199 0.586 NM_001100916
MBOAT4
membrane bound O-acyltransferase domain containing 4
chr7_+_116165043 0.579 NM_001172895
CAV1
caveolin 1, caveolae protein, 22kDa
chr12_+_7169192 0.577


chr6_+_24495166 0.576 NM_001080
NM_170740
ALDH5A1

aldehyde dehydrogenase 5 family, member A1

chr10_+_82173574 0.572 NM_001243778
NM_001243782
C10orf58

chromosome 10 open reading frame 58

chr9_+_116356407 0.571 RGS3
regulator of G-protein signaling 3
chr3_-_14989399 0.564 LOC100505641
uncharacterized LOC100505641
chr21_+_40823779 0.563 NM_007341
SH3BGR
SH3 domain binding glutamic acid-rich protein
chr11_+_77774902 0.548 NM_003251
THRSP
thyroid hormone responsive
chr1_+_154377847 0.541 IL6R
interleukin 6 receptor
chr12_+_16506350 0.536 NM_145764
MGST1
microsomal glutathione S-transferase 1
chr15_+_45248902 0.532 NM_152448
C15orf43
chromosome 15 open reading frame 43
chr15_+_66994669 0.518 NM_005585
SMAD6
SMAD family member 6
chr4_+_123653856 0.517 NM_001178007
NM_152618
BBS12

Bardet-Biedl syndrome 12

chr6_-_30043547 0.514 NM_170769
NM_025236
RNF39

ring finger protein 39

chr6_+_14117857 0.512 NM_001040280
NM_004233
CD83

CD83 molecule

chr1_+_154378044 0.511 IL6R
interleukin 6 receptor
chr19_-_49258646 0.508 NM_000148
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr17_-_15164043 0.505 NM_153322
PMP22
peripheral myelin protein 22
chr17_+_38599651 0.501 NM_001552
IGFBP4
insulin-like growth factor binding protein 4
chr14_+_95047792 0.499 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr17_+_7210929 0.487 EIF5A
eukaryotic translation initiation factor 5A
chr15_-_40633122 0.475 NM_207380
C15orf52
chromosome 15 open reading frame 52
chr15_-_72523448 0.472 PKM2
pyruvate kinase, muscle
chr6_+_24495016 0.471 ALDH5A1
aldehyde dehydrogenase 5 family, member A1
chr10_+_88718287 0.471 NM_003087
SNCG
synuclein, gamma (breast cancer-specific protein 1)
chr10_-_21785873 0.470 C10orf114
chromosome 10 open reading frame 114
chr3_+_32023265 0.470 NM_001137674
ZNF860
zinc finger protein 860
chr17_+_7211693 0.466 NM_001143762
EIF5A
eukaryotic translation initiation factor 5A
chr10_+_135160843 0.466 NM_001145201
NM_145202
PRAP1

proline-rich acidic protein 1

chr2_+_66662692 0.461 MEIS1
Meis homeobox 1
chr12_-_25055966 0.458 NM_001178093
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr2_+_66662516 0.456 NM_002398
MEIS1
Meis homeobox 1
chr19_+_17579577 0.452 SLC27A1
solute carrier family 27 (fatty acid transporter), member 1
chrX_+_106161589 0.451 NM_001171095
CLDN2
claudin 2
chr22_+_33196801 0.450 NM_000362
TIMP3
TIMP metallopeptidase inhibitor 3
chr20_+_34742656 0.446 NM_012156
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr20_+_58515408 0.445 NM_001190827
NM_022106
C20orf177

chromosome 20 open reading frame 177

chr19_+_10543110 0.437 NM_001111309
PDE4A
phosphodiesterase 4A, cAMP-specific
chr8_-_18541441 0.436 PSD3
pleckstrin and Sec7 domain containing 3
chr15_-_72523483 0.435 PKM2
pyruvate kinase, muscle
chr15_-_72523713 0.428 NM_001206796
NM_001206797
NM_001206798
NM_002654
NM_182470
NM_182471
PKM2





pyruvate kinase, muscle





chr3_-_14989857 0.428 LOC100505641
uncharacterized LOC100505641
chr17_-_27948345 0.426 NM_032854
CORO6
coronin 6
chr16_-_28550227 0.426 NUPR1
nuclear protein, transcriptional regulator, 1
chr15_-_72523542 0.424 PKM2
pyruvate kinase, muscle
chr2_+_158114109 0.422 NM_014568
GALNT5
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 (GalNAc-T5)
chr15_-_72523557 0.419 PKM2
pyruvate kinase, muscle
chr11_-_114271052 0.416 NM_019021
C11orf71
chromosome 11 open reading frame 71
chrX_-_125300079 0.415 NM_001013628
DCAF12L2
DDB1 and CUL4 associated factor 12-like 2
chr2_+_27070962 0.406 NM_020134
NM_001253723
NM_001253724
DPYSL5


dihydropyrimidinase-like 5


chr12_+_74931550 0.400 NM_001136262
ATXN7L3B
ataxin 7-like 3B
chr14_+_95047730 0.399 NM_000624
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chrX_+_49028183 0.397 NM_002668
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chrX_+_149613719 0.392 NM_001177466
NM_005491
MAMLD1

mastermind-like domain containing 1

chr15_+_90895476 0.392 NM_001004309
ZNF774
zinc finger protein 774
chr22_+_45072687 0.391 NM_001017530
NM_001198721
NM_015366
PRR5


proline rich 5 (renal)


chr9_+_74764266 0.386 NM_001242505
NM_001242506
NM_004293
GDA


guanine deaminase


chr16_-_3285069 0.384 NM_001145447
NM_003454
ZNF200

zinc finger protein 200

chr1_+_179262848 0.384 NM_001252511
NM_001252512
NM_003101
SOAT1


sterol O-acyltransferase 1


chr8_+_9953061 0.383 NM_001135671
NM_001199729
MSRA

methionine sulfoxide reductase A

chrX_+_134124967 0.380 NM_001163438
CXorf69
chromosome X open reading frame 69
chr8_-_17104266 0.377 NM_013354
NM_054026
CNOT7

CCR4-NOT transcription complex, subunit 7

chr6_-_38670920 0.373 GLO1
glyoxalase I
chr9_-_132515290 0.371 NM_004878
PTGES
prostaglandin E synthase
chr16_+_57662301 0.371 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr7_-_150652861 0.368 NM_001204798
NM_172057
KCNH2

potassium voltage-gated channel, subfamily H (eag-related), member 2

chr1_+_179262960 0.367 SOAT1
sterol O-acyltransferase 1
chr15_-_90347534 0.367 ANPEP
alanyl (membrane) aminopeptidase
chr2_+_177016112 0.367 NM_014621
HOXD4
homeobox D4
chr6_+_31583766 0.363 NM_032955
AIF1
allograft inflammatory factor 1
chr3_-_107809754 0.363 NM_001777
NM_198793
CD47

CD47 molecule

chr16_-_3285359 0.363 NM_001145448
NM_198088
NM_001145446
NM_198087
ZNF200



zinc finger protein 200



chr9_+_74764382 0.362 GDA
guanine deaminase
chr14_+_96858436 0.360 NM_152327
AK7
adenylate kinase 7
chr2_+_85766291 0.357 MAT2A
methionine adenosyltransferase II, alpha
chr14_+_95047758 0.357 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr11_-_57089670 0.356 TNKS1BP1
tankyrase 1 binding protein 1, 182kDa
chr3_-_50340979 0.355 NM_007312
NM_033159
NM_153282
NM_153283
NM_153285
HYAL1




hyaluronoglucosaminidase 1




chr4_-_155412867 0.354 NM_001142552
NM_001142553
DCHS2

dachsous 2 (Drosophila)

chr12_+_67663364 0.353 CAND1
cullin-associated and neddylation-dissociated 1
chr10_+_104503711 0.353 C10orf26
chromosome 10 open reading frame 26
chr20_+_42194736 0.352 NM_016276
SGK2
serum/glucocorticoid regulated kinase 2
chr7_+_116164838 0.351 NM_001753
CAV1
caveolin 1, caveolae protein, 22kDa
chr1_+_231114839 0.345


chr2_-_47142939 0.343 MCFD2
multiple coagulation factor deficiency 2
chr7_+_73624252 0.341 LAT2
linker for activation of T cells family, member 2
chr4_-_103266396 0.341 NM_001135147
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr12_+_100867550 0.340 NM_001206977
NM_001206978
NM_001206979
NM_005123
NR1H4



nuclear receptor subfamily 1, group H, member 4



chr12_+_100867739 0.331 NR1H4
nuclear receptor subfamily 1, group H, member 4
chrX_-_13956644 0.330 NM_001001994
GPM6B
glycoprotein M6B
chr2_-_192711651 0.330 SDPR
serum deprivation response
chr6_-_38670871 0.329 GLO1
glyoxalase I
chr8_-_17104103 0.322 CNOT7
CCR4-NOT transcription complex, subunit 7
chr17_+_7210841 0.319 NM_001970
EIF5A
eukaryotic translation initiation factor 5A
chr1_+_179262888 0.318 SOAT1
sterol O-acyltransferase 1
chrX_+_154114609 0.317 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated 2
coagulation factor VIII-associated 3
coagulation factor VIII-associated 1
chr1_+_179262936 0.316 SOAT1
sterol O-acyltransferase 1
chr15_-_90347173 0.316 ANPEP
alanyl (membrane) aminopeptidase
chrX_-_154688260 0.315 NM_001007523
NM_001007524
NM_012151
F8A2
F8A3
F8A1
coagulation factor VIII-associated 2
coagulation factor VIII-associated 3
coagulation factor VIII-associated 1
chr1_+_220960038 0.315 NM_022746
MARC1
mitochondrial amidoxime reducing component 1
chr2_-_192711923 0.311 NM_004657
SDPR
serum deprivation response
chr16_-_51185150 0.309 NM_002968
SALL1
sal-like 1 (Drosophila)
chr7_-_151574209 0.309 NM_016203
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr8_+_38243958 0.309 NM_001199659
NM_144652
LETM2

leucine zipper-EF-hand containing transmembrane protein 2

chr4_-_104020964 0.308 NM_020139
BDH2
3-hydroxybutyrate dehydrogenase, type 2
chr1_+_84767288 0.308 NM_001134663
SAMD13
sterile alpha motif domain containing 13
chr12_+_66218141 0.307 NM_003483
NM_003484
HMGA2

high mobility group AT-hook 2

chr1_+_116184573 0.307 NM_001172411
NM_138959
VANGL1

vang-like 1 (van gogh, Drosophila)

chr6_-_38670882 0.307 GLO1
glyoxalase I
chr6_+_132129154 0.305 NM_006208
ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr14_-_76447235 0.305 TGFB3
transforming growth factor, beta 3
chrX_+_105855159 0.304 NM_001184782
NM_018015
CXorf57

chromosome X open reading frame 57

chr7_-_5569200 0.302 ACTB
actin, beta
chr7_+_73624328 0.300 LAT2
linker for activation of T cells family, member 2
chr11_+_67776016 0.300 NM_001161473
ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr2_-_47143250 0.299 NM_001171507
NM_001171510
MCFD2

multiple coagulation factor deficiency 2

chrX_+_99899388 0.299 SRPX2
sushi-repeat containing protein, X-linked 2
chrX_-_54824672 0.298 NM_198510
ITIH6
inter-alpha-trypsin inhibitor heavy chain family, member 6
chr20_+_44519590 0.297 NM_000308
NM_001127695
NM_001167594
CTSA


cathepsin A


chr18_-_74729049 0.297 NM_001025081
NM_001025090
NM_001025092
NM_002385
MBP



myelin basic protein



chr17_+_7211260 0.292 NM_001143761
EIF5A
eukaryotic translation initiation factor 5A
chr1_+_154377668 0.292 NM_000565
NM_001206866
NM_181359
IL6R


interleukin 6 receptor


chr4_+_153864134 0.291 NM_033393
FHDC1
FH2 domain containing 1
chr15_-_40630272 0.290 C15orf52
chromosome 15 open reading frame 52
chr14_+_69951396 0.289 NM_001161498
PLEKHD1
pleckstrin homology domain containing, family D (with coiled-coil domains) member 1
chr6_-_38670904 0.288 GLO1
glyoxalase I
chr9_+_6215785 0.287 NM_001199640
NM_001199641
NM_033439
IL33


interleukin 33


chr7_-_150000068 0.285 NM_001164459
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr11_-_2159472 0.283 IGF2
insulin-like growth factor 2 (somatomedin A)
chr17_-_73874634 0.281 NM_033452
TRIM47
tripartite motif containing 47
chr2_+_112812799 0.278 NM_032824
TMEM87B
transmembrane protein 87B
chr4_-_84255895 0.278 NM_001199830
HPSE
heparanase
chr4_+_141264596 0.278 NM_001153446
NM_001153635
NM_001153585
NM_001153690
SCOC



short coiled-coil protein



chr17_+_48503607 0.278 ACSF2
acyl-CoA synthetase family member 2
chr6_-_38670915 0.278 GLO1
glyoxalase I
chr14_+_36295515 0.276 NM_032352
BRMS1L
breast cancer metastasis-suppressor 1-like
chr1_-_220101925 0.276 NM_018713
SLC30A10
solute carrier family 30, member 10
chr1_-_23885916 0.274 ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr6_-_38670829 0.269 GLO1
glyoxalase I
chr8_-_62602285 0.268 NM_001164750
NM_001164751
NM_001164752
NM_001164753
NM_020164
NM_032467
NM_032468
ASPH






aspartate beta-hydroxylase






chr2_+_10443020 0.268 NM_002149
HPCAL1
hippocalcin-like 1
chr1_-_153585504 0.266 NM_080388
S100A16
S100 calcium binding protein A16
chr10_+_104503724 0.264 NM_001083913
C10orf26
chromosome 10 open reading frame 26
chr7_-_73153110 0.263 ABHD11
abhydrolase domain containing 11
chr1_-_36184727 0.262 NM_152374
C1orf216
chromosome 1 open reading frame 216
chr11_+_116700620 0.261 NM_000040
APOC3
apolipoprotein C-III
chr6_-_38670922 0.260 NM_006708
GLO1
glyoxalase I
chr18_-_24129084 0.260 NM_001136205
KCTD1
potassium channel tetramerisation domain containing 1
chr1_-_27240430 0.260 NM_021969
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr1_-_220101781 0.259


chr11_-_64764388 0.259 NM_138456
BATF2
basic leucine zipper transcription factor, ATF-like 2
chr3_-_52488030 0.258 NM_003280
TNNC1
troponin C type 1 (slow)
chr19_-_12992249 0.258 NM_001375
DNASE2
deoxyribonuclease II, lysosomal
chr14_-_76447323 0.258 TGFB3
transforming growth factor, beta 3
chr8_-_62626929 0.257 ASPH
aspartate beta-hydroxylase
chr10_+_99473456 0.255 NM_031484
MARVELD1
MARVEL domain containing 1
chr6_+_132129195 0.255 ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr7_+_94285620 0.253 NM_001040152
NM_001184961
NM_001184962
NM_015068
PEG10



paternally expressed 10



chr1_-_86622107 0.253 NM_152890
COL24A1
collagen, type XXIV, alpha 1
chr11_-_66313509 0.252 NM_207340
ZDHHC24
zinc finger, DHHC-type containing 24

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

Enrichment   P-value GO Accession GO Term
422.30 1.14e-04 GO:0008191 metalloendopeptidase inhibitor activity
422.30 1.14e-04 GO:0048551 metalloenzyme inhibitor activity
383.92 1.39e-04 GO:0010576 metalloenzyme regulator activity
29.04 2.61e-02 GO:0004866 endopeptidase inhibitor activity
27.90 2.83e-02 GO:0061135 endopeptidase regulator activity
27.54 2.90e-02 GO:0030414 peptidase inhibitor activity
23.07 4.12e-02 GO:0061134 peptidase regulator activity